Esculeogenin A, a New Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting ACAT | Zendy

Yukio Fujiwara | Zendy; Naoko Kiyota | Zendy; Masaharu Hori | Zendy; Sayaka Matsushita | Zendy; Yoko Iijima | Zendy; Koh Aoki | Zendy; Daisuke Shibata | Zendy; Motohiro Takeya | Zendy; Tsuyoshi Ikeda | Zendy; Toshihiro Nohara | Zendy; Ryoji Nagai | Zendy

Open Access

Esculeogenin A, a New Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting ACAT

Author(s) -

Yukio Fujiwara,

Naoko Kiyota,

Masaharu Hori,

Sayaka Matsushita,

Yoko Iijima,

Koh Aoki,

Daisuke Shibata,

Motohiro Takeya,

Tsuyoshi Ikeda,

Toshihiro Nohara,

Ryoji Nagai

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.147405

Subject(s) - endocrinology , medicine , apolipoprotein e , hyperlipidemia , cholesterol , chemistry , sterol o acyltransferase , chinese hamster ovary cell , foam cell , triglyceride , in vitro , hamster , lipoprotein , biochemistry , biology , diabetes mellitus , receptor , disease

We recently identified esculeoside A, a new spirosolane-type glycoside, with a content in tomatoes that is 4-fold higher than that of lycopene. In the present study, we examined the effects of esculeoside A and esculeogenin A, a new aglycon of esculeoside A, on foam cell formation in vitro and atherogenesis in apoE-deficient mice.

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