Open AccessCXCR2 Blockade Impairs Angiotensin II–Induced CC Chemokine Synthesis and Mononuclear Leukocyte Infiltration
Author(s) -
Yafa Naim Abu Nabah,
Mercedes Losada,
Rossana Estellés,
Teresa Mateo,
Chantal Company,
Laura Piqueras,
Concha LópezGinés,
Henry M. Sarau,
Julio Cortijo,
Esteban J. Morcillo,
Peter J. Jose,
MaríaJesús Sanz
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.147009
Subject(s) - cxc chemokine receptors , peripheral blood mononuclear cell , chemokine , intravital microscopy , chemistry , angiotensin ii , mononuclear cell infiltration , immunology , pharmacology , chemokine receptor , inflammation , medicine , receptor , in vitro , biochemistry , microcirculation
Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II-induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved.
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