Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation | Zendy

Tomokazu Nagao | Zendy; Chunbo Qin | Zendy; Inna Grosheva | Zendy; Frederick R. Maxfield | Zendy; Lynda M. Pierini | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation

Author(s) -

Tomokazu Nagao,

Chunbo Qin,

Inna Grosheva,

Frederick R. Maxfield,

Lynda M. Pierini

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.145086

Subject(s) - rhoa , cell migration , cholesterol , foam cell , chemistry , microbiology and biotechnology , cell , macrophage , myosin , biophysics , biochemistry , lipoprotein , biology , in vitro , signal transduction

Atherogenesis begins as small subendothelial accumulations of foam cells that develop through unregulated uptake of modified and aggregated low-density lipoprotein (LDL). The reason why foam cells remain in the atherosclerotic plaque rather than migrating out of the area is unclear. We tested the hypothesis that elevated membrane cholesterol levels, which may result from interactions with aggregated LDL, affect macrophage migration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research