Open AccessRole of Protease Activated Receptor 1 and 2 Signaling in Hypoxia-Induced Angiogenesis
Author(s) -
Hannele UusitaloJärvinen,
Toru Kurokawa,
Barbara M. Mueller,
Patricia AndradeGordon,
Martin Friedlander,
Wolfram Ruf
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.142539
Subject(s) - angiogenesis , tissue factor , signal transduction , receptor , thrombin , biology , endocrinology , hypoxia (environmental) , cancer research , microbiology and biotechnology , medicine , chemistry , immunology , coagulation , biochemistry , platelet , organic chemistry , oxygen
Tissue factor (TF) initiates coagulation and indirectly triggers thrombin-dependent protease activated receptor (PAR) signaling. The TF-VIIa complex also directly cleaves PAR2 and promotes angiogenesis in vitro in TF cytoplasmic domain-deleted (TF(deltaCT)) mice. Here we address the effect of PAR1 and PAR2 deficiency on angiogenesis in vivo.
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