A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression | Zendy

Tomofumi Takaya | Zendy; Ken–ichi Hirata | Zendy; Tomoya Yamashita | Zendy; Masakazu Shinohara | Zendy; Naoto Sasaki | Zendy; Nobutaka Inoue | Zendy; Toyotaka Yada | Zendy; Masami Goto | Zendy; Akiko Fukatsu | Zendy; Toshio Hayashi | Zendy; Nicholas J. C. King | Zendy; Keith M. Chan | Zendy; Mitsuhiro Yokoyama | Zendy; Seinosuke Kawashima | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression

Author(s) -

Tomofumi Takaya,

Ken–ichi Hirata,

Tomoya Yamashita,

Masakazu Shinohara,

Naoto Sasaki,

Nobutaka Inoue,

Toyotaka Yada,

Masami Goto,

Akiko Fukatsu,

Toshio Hayashi,

Nicholas J. C. King,

Keith M. Chan,

Mitsuhiro Yokoyama,

Seinosuke Kawashima

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.142182

Subject(s) - reactive oxygen species , enos , medicine , cardiology , biology , chemistry , nitric oxide , biochemistry , nitric oxide synthase

When the availability of tetrahydrobiopterin (BH4) is deficient, endothelial nitric oxide synthase (eNOS) produces superoxide rather than NO (uncoupled eNOS). We have shown that the atherosclerotic lesion size was augmented in apolipoprotein E-deficient (ApoE-KO) mice overexpressing eNOS because of the enhanced superoxide production. In this study, we addressed the specific importance of uncoupled eNOS in atherosclerosis, and the potential mechanistic role for specific versus nonspecific antioxidant strategies in restoring eNOS coupling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research