Increased Expression of Glutathione Reductase in Macrophages Decreases Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice | Zendy

Mu Qiao | Zendy; Marta Kisgati | Zendy; Jill Cholewa | Zendy; Weifei Zhu | Zendy; Eric J. Smart | Zendy; Melanie S. Sulistio | Zendy; Reto Asmis | Zendy

Open Access

Increased Expression of Glutathione Reductase in Macrophages Decreases Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice

Author(s) -

Mu Qiao,

Marta Kisgati,

Jill Cholewa,

Weifei Zhu,

Eric J. Smart,

Melanie S. Sulistio,

Reto Asmis

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.107.142109

Subject(s) - ldl receptor , glutathione reductase , chemistry , lesion , glutathione , low density lipoprotein , lipoprotein , endocrinology , receptor , medicine , microbiology and biotechnology , biology , biochemistry , cholesterol , pathology , enzyme , glutathione peroxidase

Thiol oxidative stress leads to macrophage dysfunction and cell injury, and has been implicated in the development of atherosclerotic lesions. We investigated if strengthening the glutathione-dependent antioxidant system in macrophages by overexpressing glutathione reductase (GR) decreases the severity of atherosclerosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research