Open AccessDysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension
Author(s) -
Rory E. Morty,
Bożeejman-Faleńczyk,
Grażyna Kwapiszewska,
Matthias Hecker,
Anka Zakrzewicz,
Fotini M. Kouri,
Dorothea M. Peters,
Rio Dumitrascu,
Werner Seeger,
Petra Knaus,
Ralph T. Schermuly,
Oliver Eickelberg
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.141200
Subject(s) - bmpr2 , smad , bone morphogenetic protein , bone morphogenetic protein receptor , phosphorylation , signal transduction , bone morphogenetic protein 7 , bone morphogenetic protein 2 , medicine , endocrinology , cancer research , biology , microbiology and biotechnology , gene , biochemistry , in vitro
Mutations in the bmpr2 gene, encoding the type II bone morphogenetic protein (BMP) receptor, have been identified in patients with pulmonary arterial hypertension (PAH), implicating BMP signaling in PAH. The aim of this study was to assess BMP signaling and its physiological effects in a monocrotaline (MCT) model of PAH.
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