Open AccessExpression of Vascular Endothelial Growth Factor, Stromal Cell-Derived Factor-1, and CXCR4 in Human Limb Muscle With Acute and Chronic Ischemia
Author(s) -
Vincent van Weel,
Leonard Seghers,
Margreet R. de Vries,
Esther J. Kuiper,
Reinier O. Schlingemann,
Ingeborg M. Bajema,
J. Lindeman,
Pien M. Delisvan Diemen,
Victor W.M. van Hinsbergh,
J. Hajo van Bockel,
Paul H.A. Quax
Publication year - 2007
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.107.139642
Subject(s) - stromal cell derived factor 1 , stromal cell , angiogenesis , ischemia , medicine , vascular endothelial growth factor , cxcr4 , paracrine signalling , vascular endothelial growth factor a , pathology , endocrinology , inflammation , vegf receptors , receptor , chemokine
Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery disease.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom