Histamine Upregulates the Expression of Inducible Nitric Oxide Synthase in Human Intimal Smooth Muscle Cells via Histamine H1 Receptor and NF-κB Signaling Pathway | Zendy

Akihide Tanimoto | Zendy; KeYong Wang | Zendy; Yoshitaka Murata | Zendy; Satoshi Kimura | Zendy; Masako Nomaguchi | Zendy; Sei Nakata | Zendy; Masato Tsutsui | Zendy; Yasuyuki Sasaguri | Zendy

Open Access

Histamine Upregulates the Expression of Inducible Nitric Oxide Synthase in Human Intimal Smooth Muscle Cells via Histamine H1 Receptor and NF-κB Signaling Pathway

Author(s) -

Akihide Tanimoto,

KeYong Wang,

Yoshitaka Murata,

Satoshi Kimura,

Masako Nomaguchi,

Sei Nakata,

Masato Tsutsui,

Yasuyuki Sasaguri

Publication year - 2007

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.106.139089

Subject(s) - histamine , histamine h1 receptor , nitric oxide synthase , histamine receptor , vascular smooth muscle , histamine h4 receptor , nitric oxide , endocrinology , medicine , histamine n methyltransferase , endothelium , chemistry , receptor , signal transduction , histamine h2 receptor , biology , microbiology and biotechnology , smooth muscle , antagonist

Histamine increases endothelial nitric oxide (NO) production as an endothelium-dependent vasodilator, which acts as a vasoconstrictor in atherosclerotic coronary arteries. To investigate the relation between histamine and NO production in intimal smooth muscle cells (SMCs), we studied the effect of histamine on inducible NO synthase (iNOS) expression in the SMCs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research