Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia. | Zendy

Thomas W. Furlow | Zendy; John M. Hallenbeck | Zendy

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Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia.

Author(s) -

Thomas W. Furlow,

John M. Hallenbeck

Publication year - 1978

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.9.6.591

Subject(s) - medicine , ischemia , perfusion , vasoconstriction , anesthesia , central nervous system , circulatory system , cerebral blood flow , blood flow , brain ischemia , prostaglandin , cardiology

Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by preventing vasoconstriction and by anti-hemostatic effects on blood.

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