Prevention of persistent cerebral smooth muscle contraction in response to whole blood. | Zendy

M. Linder | Zendy; John F. Alksne | Zendy

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Prevention of persistent cerebral smooth muscle contraction in response to whole blood.

Author(s) -

M. Linder,

John F. Alksne

Publication year - 1978

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.9.5.472

Subject(s) - medicine , contraction (grammar) , constriction , platelet , anesthesia , whole blood , muscle contraction , vasospasm , cardiology , vasoconstriction , blood platelet disorders , pharmacology , platelet aggregation , subarachnoid hemorrhage

Using an in vitro system designed to measure arterial constriction, we have demonstrated the importance of platelet function in maintaining cerebral smooth muscle contraction after whole blood injection. We tested two agents, acetyl salicylic acid (ASA) and phthalazinol, both known to interfere with platelet function. In control tests normal rabbit and monkey blood produced a reliable and persistent arterial constriction. In experimental tests blood drawn from animals premedicated with ASA and phthalazinol failed to produce a persistent contraction. These results support the hypothesis that chemicals released during platelet aggregation may be important in persistent vasospasm.

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