Experimental cerebral infarction. Part 1: Production of thalamic infarction in dogs. | Zendy

Takashi Yoshimoto | Zendy; Tetsuya Sakamoto | Zendy; Jirô Suzuki | Zendy

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Experimental cerebral infarction. Part 1: Production of thalamic infarction in dogs.

Author(s) -

Takashi Yoshimoto,

Tetsuya Sakamoto,

Jirô Suzuki

Publication year - 1978

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.9.3.211

Subject(s) - medicine , thalamus , cerebral infarction , infarction , occlusion , ischemia , cardiology , cerebral arteries , posterior cerebral artery , stroke (engine) , middle cerebral artery , anesthesia , radiology , myocardial infarction , mechanical engineering , engineering

Difficulties in achieving focal temporary cerebral ischemia in experimental animals have delayed study of the prevention and treatment of cerebral infarction. We have succeeded in producing focal cerebral infarction by temporary occlusion of brain arteries. Infarction confined to the anterior portion of the thalamus was obtained by simultaneous occlusion of the 4 cerebral arteries: internal carotid, anterior cerebral, middle cerebral and posterior communicating arteries for 60-120 minutes. This experimental model in dogs is unique, since thalamic infarction can be produced with high frequency, and the dogs can be kept alive and managed for sufficient periods after temporary artery clipping. With this model it is possible to investigate cerebral infarction not only from the pathophysiological viewpoint, but also from the viewpoint of prevention and treatment of cerebral infarction in man.

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