Effect of carotid artery ligation on regional cerebral blood flow in normotensive and spontaneously hypertensive rats. | Zendy

J Choki | Zendy; Takenori Yamaguchi | Zendy; Y Takeya | Zendy; Yasuyuki Morotomi | Zendy; T Omae | Zendy

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Effect of carotid artery ligation on regional cerebral blood flow in normotensive and spontaneously hypertensive rats.

Author(s) -

J Choki,

Takenori Yamaguchi,

Y Takeya,

Yasuyuki Morotomi,

T Omae

Publication year - 1977

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.8.3.374

Subject(s) - medicine , ligation , cerebral blood flow , carotid arteries , blood pressure , cardiology , common carotid artery , anesthesia , blood flow , ischemia , spontaneously hypertensive rat , external carotid artery , hemodynamics

Regional cerebral blood flow (rCBF) was measured in normotensive rate (NTR) and spontaneously hypertensive rats (SHR), in a lightly anesthetized state and with control of PaCO2 by artificial ventilation. Without carotid artery ligation, NTR and SHR showed almost identical rCBF values and distribution, despite significantly elevated levels of blood pressure in SHR. Bilateral carotid artery ligation, however, caused much more pronounced decreases of rCBF (ischemia) in SHR than NTR, in regions supplied by the carotid artery. The reduction of rCBF in SHR was rather homogenous and symmetrical. Mechanisms causing the differences between NTR and SHR are discussed.

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