Direct evidence for absence of beta-adrenergic receptors in rat cerebral vessels histochemical study with a fluorescent beta-blocker. | Zendy

E. Melamed | Zendy; Daphné Atlas | Zendy; Moshe Lahav | Zendy

Open Access

Direct evidence for absence of beta-adrenergic receptors in rat cerebral vessels histochemical study with a fluorescent beta-blocker.

Author(s) -

E. Melamed,

Daphné Atlas,

Moshe Lahav

Publication year - 1977

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.8.2.261

Subject(s) - propranolol , adrenergic receptor , receptor , medicine , adrenergic , beta (programming language) , endocrinology , beta 1 adrenergic receptor , fluorescence , computer science , programming language , physics , quantum mechanics

A fluorescent marker for beta-adrenergic receptor sites, 9-amino-acridin propranolol (9-AAP), was administered intravenously to rats. In contrast to other tissues which are known to contain beta-adrenergic receptors, 9-AAP fluorescence was not observed in the walls of the pial as well as parenchymal cerebral vessels. These negative findings strongly suggest that in the rat, beta-adrenergic receptors are not present in the cerebral vasculature. The role of the alpha-adrenergic receptors needs more study.

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