Studies on the cerebral circulation of the baboon in acutely induced hypertension. | Zendy

Svend Strandgaard | Zendy; Eric T. MacKenzie | Zendy; J V Jones | Zendy; A. M. Harper | Zendy

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Studies on the cerebral circulation of the baboon in acutely induced hypertension.

Author(s) -

Svend Strandgaard,

Eric T. MacKenzie,

J V Jones,

A. M. Harper

Publication year - 1976

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.7.3.287

Subject(s) - medicine , autoregulation , baboon , blood pressure , cerebral blood flow , cerebral circulation , vascular resistance , anesthesia , cerebral autoregulation , cardiology

The upper limit autoregulation of cerebral blood flow was investigated in eight young baboons with the intracarotid 133xenon clearance method. Blood pressure was increased by intravenous angiotensin infusion. Autoregulation was effective during blood pressure increase from normotensive levels to a mean pressure of 130 to 139 mm Hg. At this pressure, cerebrovascular resistance reached a maximum. With further blood pressure increase, autoregulation was broken, and the vascular resistance dropped significantly. This flow increase was restricted to the fast component of the 133xenon clearance curve, leaving slow component unchanged.

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