Abnormal cerebrovascular response to altered PaCO2 in baboons with obstructive jaundice. | Zendy

T A McCalden | Zendy; Benjamin H. Eidelman | Zendy; D. S. Bloom | Zendy

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Abnormal cerebrovascular response to altered PaCO2 in baboons with obstructive jaundice.

Author(s) -

T A McCalden,

Benjamin H. Eidelman,

D. S. Bloom

Publication year - 1976

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.7.2.190

Subject(s) - normocapnia , hypercapnia , medicine , hypocapnia , hyperventilation , phentolamine , blockade , obstructive jaundice , anesthesia , cardiology , acidosis , propranolol , receptor

The cerebrovascular response to hypercapnia and hyperventilation was studied in normal and jaundiced baboons by the intracarotid 133Xe injection technique. The baboons with bile duct ligation were found to have decreased CBF at all levels of PaCO2. This difference between normal and jaundiced baboons was 13% at normocapnia rising to 33% with hypercapnia and 37% with hypocapnia. The CBF values all were increased toward normal by use of an alpha-adrenoreceptor blockade (phentolamine). It is suggested that the obstructive jaundice potentiated an inherent vasoconstrictor alpha-adrenergic mechanism to oppose the effects of CO2. Also, alteration of the PaCO2 may have produced its effects on the cerebral vessels by altering this adrenergic mechanism.

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