Open AccessLimitations of diazoxide reversal of vasospasm.
Author(s) -
R C Heros,
Michael H. Lavyne,
N T Zervas
Publication year - 1976
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.7.2.118
Subject(s) - medicine , vasospasm , diazoxide , anesthesia , cerebral vasospasm , subarachnoid hemorrhage , insulin
Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypotension and, in the presence of vasospasm, was associated with a high mortality rate.
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