A Paradoxical Cerebral Hemodynamic Effect of Hydralazine | Zendy

J. Overgaard | Zendy; E Skinhöj | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Paradoxical Cerebral Hemodynamic Effect of Hydralazine

Author(s) -

J. Overgaard,

E Skinhöj

Publication year - 1975

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.6.4.402

Subject(s) - hydralazine , medicine , hyperventilation , hemodynamics , cerebral perfusion pressure , cerebral blood flow , vasodilation , blood pressure , anesthesia , cardiology , vascular resistance , cerebral circulation , perfusion

Hydralazine is shown to have a very complex cerebral hemodynamic effect. It raises the intracranial pressure which, together with its effect upon systemic blood pressure, reduces the cerebral perfusion pressure. In spite of this and a concomitantly induced hyperventilation by hydralazine, CBF increases with some delay. The conclusion is that hydralazine is a cerebral vasodilator acting immediately upon cerebral capacitance vessels but later upon the resistance vessels as well.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research