Endothelial Cell Ischemic Injury: Protective Effect of Heparin or Aspirin Assessed by Scanning Electron Microscopy | Zendy

S. David Gertz | Zendy; Marshall L. Rennels | Zendy; Erland Nelson | Zendy

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Endothelial Cell Ischemic Injury: Protective Effect of Heparin or Aspirin Assessed by Scanning Electron Microscopy

Author(s) -

S. David Gertz,

Marshall L. Rennels,

Erland Nelson

Publication year - 1975

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.6.4.357

Subject(s) - medicine , aspirin , heparin , scanning electron microscope , endothelial stem cell , occlusion , pathology , cardiology , in vitro , biochemistry , chemistry , physics , quantum mechanics

Scanning electron microscopic observations of the luminal surface of the rabbit common carotid artery subjected to occlusion for 30 minutes or two hours revealed crater-like and balloon-like defects in the endothelial surface. The frequency of occurrence of these abnormalities was significantly decreased by pretreatment with heparin or aspirin in doses considered to have antiplatelet aggregating activity.

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