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To test the effectiveness of betahistine HCl in reducing the frequency of transient ischemic attacks (TIAs) caused by vertebral-basilar artery insufficiency, we randomly assigned 26 patients with a typical history of the condition to a placebo-drug or a drug-placebo sequence, each sequence lasting two months. During the study, the frequency of TIAs did not differ significantly between the placebo and the drug groups. Subjective responses indicated some value for betahistine as a palliative agent.

A Comparison of Betahistine Hydrochloride With Placebo for Vertebral-Basilar Insufficiency: A Double-Blind Study