Cerebral Anoxia: An Improved In Vitro Model for Biochemical Study | Zendy

Takehiko Yanagihara | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cerebral Anoxia: An Improved In Vitro Model for Biochemical Study

Author(s) -

Takehiko Yanagihara

Publication year - 1973

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.4.3.409

Subject(s) - anoxic waters , in vitro , medicine , cerebral anoxia , cerebral cortex , oxygen , anesthesia , biochemistry , biology , chemistry , environmental chemistry , organic chemistry

A previously described in vitro model for cerebral anoxia has been modified to ensure vitality of the rabbit brain slices. The oxygen or nitrogen atmosphere was provided by a continuous gas flow system. Amino acid incorporation into proteins was studied during recovery periods up to 60 minutes. An initial decrease of incorporation and subsequent recovery were observed after an anoxic period of five minutes. On the other hand, a marked decrease and only partial recovery were seen after anoxic periods of 15 minutes or longer. No consistent change was observed in acid-soluble radioactivity. This in vitro model appears to be feasible for various biochemical studies of cerebral anoxia.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research