A Study of Regional Autoregulation in the Cerebral Circulation to Increased Perfusion Pressure in Normocapnia and Hypercapnia | Zendy

L. Symon | Zendy; Klaus Held | Zendy; Nicholas W.C. Dorsch | Zendy

Open Access

A Study of Regional Autoregulation in the Cerebral Circulation to Increased Perfusion Pressure in Normocapnia and Hypercapnia

Author(s) -

L. Symon,

Klaus Held,

Nicholas W.C. Dorsch

Publication year - 1973

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.4.2.139

Subject(s) - medicine , normocapnia , cerebral perfusion pressure , hypercapnia , anesthesia , cerebral autoregulation , middle cerebral artery , autoregulation , perfusion , cerebral circulation , cardiology , cerebral blood flow , ischemia , blood pressure , acidosis

Catheterization of Labbé's vein and of a pial branch of the middle cerebral artery has been performed on anesthetized baboons. Closure of the skull has enabled the reaction of the venous outflow from Labbé's vein to be monitored in response to pressure step increases in the pial arterial pressure induced by gas compression of a perfusion mixture connected to the arterial line. Rapid changes in cerebrovascular resistance with swift emergence of regulatory constancy have been shown, and the time characteristics of the resistance changes strongly suggest that they are primarily myogenic in origin. Induction of hypercapnia did not interfere with this autoregulatory mechanism to increased perfusion pressure, which indeed appeared to be more effective at raised arterial PCO2, but the mechanism was abolished by the induction of ischemia from middle cerebral occlusion.

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