Open-Label Dose-Titration Safety and Efficacy Study of Tizanidine Hydrochloride in the Treatment of Spasticity Associated With Chronic Stroke | Zendy

David A. Gelber | Zendy; David C. Good | Zendy; Alexander W. Dromerick | Zendy; Stephen M. Sergay | Zendy; Melissa Richardson | Zendy

Open Access

Open-Label Dose-Titration Safety and Efficacy Study of Tizanidine Hydrochloride in the Treatment of Spasticity Associated With Chronic Stroke

Author(s) -

David A. Gelber,

David C. Good,

Alexander W. Dromerick,

Stephen M. Sergay,

Melissa Richardson

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.8.1841

Subject(s) - tizanidine , spasticity , medicine , modified ashworth scale , muscle tone , anesthesia , muscle relaxant , stroke (engine) , somnolence , physical therapy , adverse effect , muscle spasm , hemiparesis , physical medicine and rehabilitation , mechanical engineering , engineering , angiography

Spasticity is a frequently observed motor impairment that develops after stroke; it can cause pain and disability in those affected. The objective of the present study was to evaluate the safety and efficacy of tizanidine, a centrally acting alpha(2)-adrenergic agonist, in the treatment of stroke-related spasticity.

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