Transgenic CuZn-Superoxide Dismutase Inhibits NO Synthase Induction in Experimental Subarachnoid Hemorrhage | Zendy

Atsushi Saito | Zendy; Hideyuki Kamii | Zendy; Ichiro Kato | Zendy; Shin Takasawa | Zendy; Takeo Kondo | Zendy; Pak H. Chan | Zendy; Hiroshi Okamoto | Zendy; Takashi Yoshimoto | Zendy

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Transgenic CuZn-Superoxide Dismutase Inhibits NO Synthase Induction in Experimental Subarachnoid Hemorrhage

Author(s) -

Atsushi Saito,

Hideyuki Kamii,

Ichiro Kato,

Shin Takasawa,

Takeo Kondo,

Pak H. Chan,

Hiroshi Okamoto,

Takashi Yoshimoto

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.7.1652

Subject(s) - medicine , superoxide dismutase , subarachnoid hemorrhage , nitric oxide synthase , oxidative stress , nitric oxide

The expression of inducible NO synthase (iNOS) after experimental subarachnoid hemorrhage (SAH) has been postulated to play a critical role in the pathogenesis of SAH and subsequent cerebral vasospasm. The inhibitory effect of CuZn-superoxide dismutase (CuZn-SOD) on the induction of iNOS after SAH was examined by using transgenic mice overexpressing CuZn-SOD.

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