Middle Cerebral Artery Occlusion and Reperfusion in Primates Monitored by Microdialysis and Sequential Positron Emission Tomography | Zendy

Per Enblad | Zendy; Peter Frykholm | Zendy; Johann Valtysson | Zendy; Hans C son Silander | Zendy; Jesper Andersson | Zendy; KarlJohan Fasth | Zendy; Yasuyoshi Watanabe | Zendy; Bengt Långström | Zendy; Lars Hillered | Zendy; Lennart Persson | Zendy

Open Access

Middle Cerebral Artery Occlusion and Reperfusion in Primates Monitored by Microdialysis and Sequential Positron Emission Tomography

Author(s) -

Per Enblad,

Peter Frykholm,

Johann Valtysson,

Hans C son Silander,

Jesper Andersson,

KarlJohan Fasth,

Yasuyoshi Watanabe,

Bengt Långström,

Lars Hillered,

Lennart Persson

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.7.1574

Subject(s) - medicine , positron emission tomography , microdialysis , occlusion , tomography , nuclear medicine , middle cerebral artery , ischemia , radiology , anesthesia , cardiology , central nervous system

In a previous investigation concerning the hemodynamic and metabolic changes over time displayed by sequential positron emission tomography (PET) in a middle cerebral artery (MCA) occlusion/reperfusion primate model, a metabolic threshold for irreversible ischemia could be identified (reduction of metabolic rate of oxygen [CMRO(2)] to approximately 60% of the contralateral hemisphere). To evaluate the potential of microdialysis (MD) as an instrument for chemical brain monitoring, the aim of this subsequent study was to relate the chemical changes in MD levels directly to the regional metabolic status (CMRO(2) above or below the metabolic threshold) and the occurrence of reperfusion, as assessed by PET.

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