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Angiotensin-Converting Enzyme Inhibition With Enalapril Slows Progressive Intima-Media Thickening of the Common Carotid Artery in Patients With Non–Insulin-Dependent Diabetes Mellitus
Author(s) -
Naohisa Hosomi,
Katsufumi Mizushige,
Hideo Ohyama,
Tsutomu Takahashi,
Masaya Kitadai,
Yoshio Hatanaka,
Hirohíde Matsuo,
Masakazu Kohno,
James A. Koziol
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.7.1539
Subject(s) - enalapril , medicine , diabetes mellitus , angiotensin converting enzyme , ace inhibitor , cardiology , thickening , insulin , common carotid artery , lumen (anatomy) , endocrinology , carotid arteries , blood pressure , chemistry , polymer science
Whether angiotensin-converting enzyme (ACE) inhibitors have any clinically significant antiatherogenic effects in humans remains unproven. We undertook a prospective randomized clinical trial of 98 patients with non-insulin-dependent diabetes mellitus (NIDDM) to examine the efficacy of ACE inhibition with enalapril for preventing intima-media (IM) thickening of the carotid wall as measured ultrasonographically.

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