Effect of Apolipoprotein E Genotype on Cerebral Autoregulation During Cardiopulmonary Bypass | Zendy

Lian Kah Ti | Zendy; Joseph P. Mathew | Zendy; G. Burkhard Mackensen | Zendy; Hilary P. Grocott | Zendy; William D. White | Zendy; J. G. Rêves | Zendy; Mark F. Newman | Zendy

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Effect of Apolipoprotein E Genotype on Cerebral Autoregulation During Cardiopulmonary Bypass

Author(s) -

Lian Kah Ti,

Joseph P. Mathew,

G. Burkhard Mackensen,

Hilary P. Grocott,

William D. White,

J. G. Rêves,

Mark F. Newman

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.7.1514

Subject(s) - medicine , cardiopulmonary bypass , autoregulation , cerebral blood flow , cerebral autoregulation , apolipoprotein e , cardiology , anesthesia , hemodynamics , hypothermia , blood pressure , disease

The presence of the apolipoprotein E epsilon4 (apoE4) allele has been associated with cognitive decline after cardiac surgery. We compared autoregulation of cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO(2)), and arterial-venous oxygen content difference [C(A-V)O(2)], during cardiopulmonary bypass (CPB) in patients with and without the apoE4 allele to help define the mechanism of association with cognitive decline.

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