Early Decrease in DNA Repair Proteins, Ku70 and Ku86, and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice | Zendy

Gyung Whan Kim | Zendy; Nobuo Noshita | Zendy; Taku Sugawara | Zendy; Pak H. Chan | Zendy

Open Access

Early Decrease in DNA Repair Proteins, Ku70 and Ku86, and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice

Author(s) -

Gyung Whan Kim,

Nobuo Noshita,

Taku Sugawara,

Pak H. Chan

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.6.1401

Subject(s) - tunel assay , ku70 , dna fragmentation , microbiology and biotechnology , in situ nick end labeling , western blot , dna damage , ischemia , medicine , dna repair , blot , immunohistochemistry , pathology , apoptosis , dna , biology , biochemistry , gene , programmed cell death

Ku70 and Ku86, multifunctional DNA repair proteins, bind to broken DNA ends, including double-strand breaks, and trigger a DNA repair pathway. To investigate the involvement of these proteins in DNA fragmentation after ischemia/reperfusion, Ku protein expression was examined before and after transient focal cerebral ischemia (FCI) in mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research