Rapid Differential Endogenous Plasminogen Activator Expression After Acute Middle Cerebral Artery Occlusion | Zendy

Naohisa Hosomi | Zendy; Jacinta Lucero | Zendy; Ji Hoe Heo | Zendy; James A. Koziol | Zendy; Brian R. Copeland | Zendy; Gregory J. del Zoppo | Zendy

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Rapid Differential Endogenous Plasminogen Activator Expression After Acute Middle Cerebral Artery Occlusion

Author(s) -

Naohisa Hosomi,

Jacinta Lucero,

Ji Hoe Heo,

James A. Koziol,

Brian R. Copeland,

Gregory J. del Zoppo

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.6.1341

Subject(s) - medicine , tissue plasminogen activator , middle cerebral artery , urokinase , t plasminogen activator , plasminogen activator , plasmin , basal lamina , basal ganglia , ischemia , matrix metalloproteinase , endogeny , intracerebral hemorrhage , endocrinology , pathology , central nervous system , biology , enzyme , biochemistry , subarachnoid hemorrhage , ultrastructure

During focal cerebral ischemia, the microvascular matrix (ECM), which participates in microvascular integrity, is degraded and lost when neurons are injured. Loss of microvascular basal lamina antigens coincides with rapid expression of select matrix metalloproteinases (MMPs). Plasminogen activators (PAs) may also play a role in ECM degradation by the generation of plasmin or by MMP activation.

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