Ethical and Methodological Issues in Pedigree Stroke Research | Zendy

Bradford B. Worrall | Zendy; Donna T. Chen | Zendy; James F. Meschia | Zendy

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Ethical and Methodological Issues in Pedigree Stroke Research

Author(s) -

Bradford B. Worrall,

Donna T. Chen,

James F. Meschia

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.6.1242

Subject(s) - proband , confidentiality , pedigree chart , informed consent , medicine , genetic counseling , protocol (science) , identification (biology) , research ethics , inheritance (genetic algorithm) , psychiatry , genetics , computer science , computer security , alternative medicine , pathology , botany , gene , mutation , biology

Stroke is a complex genetic disorder with a variable phenotype. Investigations of heritable factors in complex genetic disorders use pedigree and genetic techniques, which pose different ethical and methodological challenges than those routinely encountered in therapeutic research. Building consensus on acceptable research practices in this field is vital to the success of multicentered collaborations.

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