Delayed Neuroprotective Effect of Insulin-Like Growth Factor-I After Experimental Transient Focal Cerebral Ischemia Monitored With MRI | Zendy

Wolf-R. Schäbitz | Zendy; Tobias T. Hoffmann | Zendy; Sabine Heiland | Zendy; Rainer Kollmar | Zendy; Juergen Bardutzky | Zendy; Claudia Sommer | Zendy; Stefan Schwab | Zendy

Open Access

Delayed Neuroprotective Effect of Insulin-Like Growth Factor-I After Experimental Transient Focal Cerebral Ischemia Monitored With MRI

Author(s) -

Wolf-R. Schäbitz,

Tobias T. Hoffmann,

Sabine Heiland,

Rainer Kollmar,

Juergen Bardutzky,

Claudia Sommer,

Stefan Schwab

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.5.1226

Subject(s) - medicine , neuroprotection , ischemia , anesthesia , occlusion , middle cerebral artery , magnetic resonance imaging , placebo , infarction , perfusion scanning , perfusion , pathology , radiology , alternative medicine , myocardial infarction

Insulin-like growth factor (IGF) treatment has been shown to have trophic and neuroprotective effects in vitro and in vivo in different lesion models. IGF-I has potent neuroprotective effects after hypoxic-ischemic injury and global ischemia. The role of IGF-I in focal cerebral ischemia is only partially understood. Therefore, in the present study, we evaluated, by applying MRI monitoring, whether a clinically relevant systemic administration of IGF-I can achieve a long-lasting neuroprotective effect.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research