White Matter Damage Is Associated With Matrix Metalloproteinases in Vascular Dementia | Zendy

Gary A. Rosenberg | Zendy; Niky Sullivan | Zendy; Margaret M. Esiri | Zendy

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White Matter Damage Is Associated With Matrix Metalloproteinases in Vascular Dementia

Author(s) -

Gary A. Rosenberg,

Niky Sullivan,

Margaret M. Esiri

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.5.1162

Subject(s) - medicine , vascular dementia , pathology , gliosis , white matter , matrix metalloproteinase , dementia , glial fibrillary acidic protein , hyaline , disease , immunohistochemistry , magnetic resonance imaging , radiology

Vascular disease causes multi-infarct dementia (MID) or Binswanger's disease (BD), the latter of which is a progressive form of vascular dementia (VaD) associated pathologically with fibrinoid and hyaline changes in brain arterioles with injury to the white matter. Clinically, BD patients have long-standing hypertension with disturbances of gait and intellect. Because matrix metalloproteinases (MMPs) are important in cerebral infarction, we hypothesized that disturbances in the MMPs may be involved in VAD:

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