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Elevated Plasma Homocysteine Levels and Risk of Silent Brain Infarction in Elderly People
Author(s) -
Toshifumi Matsui,
Hiroyuki Arai,
Takefumi Yuzuriha,
Hiroshi Yao,
Masakazu Miura,
Setsuko Hashimoto,
Susumu Higuchi,
Sachio Matsushita,
Masatoshi Morikawa,
Atsushi Kato,
Hidetada Sasaki
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.5.1116
Subject(s) - medicine , homocysteine , hyperhomocysteinemia , methylenetetrahydrofolate reductase , stroke (engine) , renal function , univariate analysis , myocardial infarction , vitamin d and neurology , gastroenterology , multivariate analysis , mechanical engineering , biochemistry , chemistry , genotype , gene , engineering
Silent brain infarction (SBI) on MRI is common in elderly people, and recent studies have demonstrated that SBI increases the risk of progression to clinically apparent stroke and cognitive decline. Therefore, an early and accurate detection of SBI and a search for potential treatable risk factors may have a significant impact on public health.

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