Improving the Reliability of Stroke Subgroup Classification Using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Criteria | Zendy

Larry B. Goldstein | Zendy; Michael R. Jones | Zendy; David B. Matchar | Zendy; Lloyd J. Edwards | Zendy; Jennifer Hoff | Zendy; Vani Chilukuri | Zendy; S. Beth Armstrong | Zendy; Ronnie D. Horner | Zendy

Open Access

Improving the Reliability of Stroke Subgroup Classification Using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Criteria

Author(s) -

Larry B. Goldstein,

Michael R. Jones,

David B. Matchar,

Lloyd J. Edwards,

Jennifer Hoff,

Vani Chilukuri,

S. Beth Armstrong,

Ronnie D. Horner

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.5.1091

Subject(s) - medicine , stroke (engine) , acute stroke , subgroup analysis , clinical trial , confidence interval , mechanical engineering , tissue plasminogen activator , engineering

We sought to improve the reliability of the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification of stroke subtype for retrospective use in clinical, health services, and quality of care outcome studies. The TOAST investigators devised a series of 11 definitions to classify patients with ischemic stroke into 5 major etiologic/pathophysiological groupings. Interrater agreement was reported to be substantial in a series of patients who were independently assessed by pairs of physicians. However, the investigators cautioned that disagreements in subtype assignment remain despite the use of these explicit criteria and that trials should include measures to ensure the most uniform diagnosis possible.

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