Open AccessAdenovirus-Mediated Gene Transfer to Ischemic Brain
Author(s) -
Hiroaki Ooboshi,
Setsuro Ibayashi,
Junichi Takada,
Hiroshi Yao,
Takanari Kitazono,
Masatoshi Fujishima
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.4.1043
Subject(s) - medicine , ischemia , brain ischemia , cerebral blood flow , middle cerebral artery , gene expression , blood flow , transgene , genetic enhancement , pathology , anesthesia , gene , biology , biochemistry
Gene therapy may be a promising approach for treatment of brain ischemia, although protein synthesis is generally inhibited in ischemic conditions. Our goal in this study was to examine effects of brain ischemia on transgene expression of adenovirus-mediated gene transfer to ischemic brain.
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