Calbindin D28K Overexpression Protects Striatal Neurons From Transient Focal Cerebral Ischemia | Zendy

Midori A. Yenari | Zendy; Masabumi Minami | Zendy; Guo Hua Sun | Zendy; Timothy J. Meier | Zendy; David M. Kunis | Zendy; John R. McLaughlin | Zendy; Dora Y. Ho | Zendy; Robert M. Sapolsky | Zendy; Gary K. Steinberg | Zendy

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Calbindin D28K Overexpression Protects Striatal Neurons From Transient Focal Cerebral Ischemia

Author(s) -

Midori A. Yenari,

Masabumi Minami,

Guo Hua Sun,

Timothy J. Meier,

David M. Kunis,

John R. McLaughlin,

Dora Y. Ho,

Robert M. Sapolsky,

Gary K. Steinberg

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.4.1028

Subject(s) - medicine , neuroprotection , striatum , ischemia , calbindin , stroke (engine) , calcium , pathology , endocrinology , dopamine , mechanical engineering , engineering

Increased intracellular calcium accumulation is known to potentiate ischemic injury. Whether endogenous calcium-binding proteins can attenuate this injury has not been clearly established, and existing data are conflicting. Calbindin D28K (CaBP) is one such intracellular calcium buffer. We investigated whether CaBP overexpression is neuroprotective against transient focal cerebral ischemia.

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