Efficacy of Antioxidant Therapies in Transient Focal Ischemia in Mice | Zendy

Wayne M. Clark | Zendy; Lisa G. Rinker | Zendy; Nikola Lessov | Zendy; Stuart L. Lowery | Zendy; Marilyn J. Cipolla | Zendy

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Efficacy of Antioxidant Therapies in Transient Focal Ischemia in Mice

Author(s) -

Wayne M. Clark,

Lisa G. Rinker,

Nikola Lessov,

Stuart L. Lowery,

Marilyn J. Cipolla

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.4.1000

Subject(s) - medicine , neuroprotection , anesthesia , ginkgo biloba , ischemia , stroke (engine) , placebo , pharmacology , antioxidant , middle cerebral artery , cardiology , pathology , biochemistry , mechanical engineering , chemistry , alternative medicine , engineering

Ginkgo biloba extract (EGb) and alpha-lipoic acid (LA) are commercially available "antioxidant supplements" with a variety of actions that may be beneficial during acute stroke. These actions include inhibiting platelet and leukocyte activation and adhesion, reducing free radical generation, and increasing cerebral blood flow. Both EGb and LA have been shown to be neuroprotective in cell culture and global central nervous system ischemia models. In this study we investigated the neuroprotective efficacy of EGb and LA in a clinically relevant, transient focal central nervous system ischemic model.

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