Electrophysiological Properties of CA1 Neurons Protected by Postischemic Hypothermia in Gerbils
Author(s) -
Hui Dong,
F. MoodyCorbett,
Frederick Colbourne,
Quentin J. Pittman,
Dale Corbett
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.3.788
Subject(s) - medicine , electrophysiology , hypothermia , neuroscience , ischemia , anesthesia , gerbil , cardiology , biology
Recent studies show that prolonged (eg, 24-hour) postischemic hypothermia confers lasting histological and behavioral protection against severe global cerebral ischemia. However, functional abnormalities may be compensated for by undamaged brain regions and thus not detected by behavioral tests. To determine whether hypothermia preserves CA1 functional integrity, we measured synaptic and membrane properties of CA1 neurons in ischemic gerbils treated with postischemic hypothermia.
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