Anticonvulsant Lamotrigine Administered on Reperfusion Fails To Improve Experimental Stroke Outcomes | Zendy

Richard J. Traystman | Zendy; Judith A. Klaus | Zendy; A. Courtney DeVries | Zendy; Amanda B. Shaivitz | Zendy; Patricia D. Hurn | Zendy

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Anticonvulsant Lamotrigine Administered on Reperfusion Fails To Improve Experimental Stroke Outcomes

Author(s) -

Richard J. Traystman,

Judith A. Klaus,

A. Courtney DeVries,

Amanda B. Shaivitz,

Patricia D. Hurn

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.3.783

Subject(s) - medicine , anesthesia , ischemia , infarction , stroke (engine) , saline , mechanical engineering , myocardial infarction , engineering

Recent results suggest that selective inhibitors of presynaptic neuronal ion channels can diminish glutamate release during cerebral ischemia and modulate excitotoxic cell death. The aim of the present study was to evaluate lamotrigine (LTG), an antiepileptic that inhibits presynaptic sodium and voltage-sensitive calcium channels, as a potential stroke resuscitation agent in the rat. Three dosages of LTG were examined for effect on infarction volume and sensorimotor behavioral recovery after middle cerebral artery (MCA) occlusion.

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