A Common Variant of Endothelial Nitric Oxide Synthase (Glu298Asp) Is an Independent Risk Factor for Carotid Atherosclerosis | Zendy

Giuseppe Lembo | Zendy; Nicola De Luca | Zendy; Cristina Battagli | Zendy; G Iovino | Zendy; Alessandra Aretini | Zendy; Massimo Musicco | Zendy; Giacomo Frati | Zendy; Francesco Pompeo | Zendy; Carmine Vecchione | Zendy; Bruno Trimarco | Zendy

Open Access

A Common Variant of Endothelial Nitric Oxide Synthase (Glu298Asp) Is an Independent Risk Factor for Carotid Atherosclerosis

Author(s) -

Giuseppe Lembo,

Nicola De Luca,

Cristina Battagli,

G Iovino,

Alessandra Aretini,

Massimo Musicco,

Giacomo Frati,

Francesco Pompeo,

Carmine Vecchione,

Bruno Trimarco

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.3.735

Subject(s) - medicine , risk factor , nitric oxide synthase , nitric oxide , endothelial nitric oxide synthase , cardiology , endocrinology , enos

Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS) encoded by the NOS 3 gene on chromosome 7. Because several studies have indicated that NO plays a key role in the development of the atherosclerotic process, we investigated whether common variants in the eNOS gene are associated with an increased risk of plaque on carotid arteries.

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