Caspase Inhibitors Attenuate Oxyhemoglobin-Induced Apoptosis in Endothelial Cells | Zendy

Toshinari Meguro | Zendy; Betty Chen | Zendy; Andrew D. Parent | Zendy; John H. Zhang | Zendy

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Caspase Inhibitors Attenuate Oxyhemoglobin-Induced Apoptosis in Endothelial Cells

Author(s) -

Toshinari Meguro,

Betty Chen,

Andrew D. Parent,

John H. Zhang

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.2.561

Subject(s) - poly adp ribose polymerase , apoptosis , proteases , microbiology and biotechnology , caspase , caspase 3 , endothelial stem cell , cytotoxic t cell , caspase 9 , programmed cell death , biology , biochemistry , polymerase , enzyme , in vitro

Our recent study showed that oxyhemoglobin (OxyHb) induces apoptosis in cultured endothelial cells. Apoptosis requires the action of various classes of proteases, including a family of cysteine proteases known collectively as the caspases. This study was undertaken to investigate the effect of 2 caspase inhibitors, Z-VDVAD-FMK and Z-DEVD-FMK, in the protection of endothelial cells from OxyHb-induced apoptosis.

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