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Spermidine: A Predictor for Neurological Outcome and Infarct Size in Focal Cerebral Ischemia?
Author(s) -
T. Els,
J.U. Brückmann,
Gabriele Röhn,
Michael Daffertshofer,
Jürgen Schulte Mönting,
R.-I. Ernestus,
M.G. Hennerici
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.1.43
Subject(s) - medicine , ischemia , polyamine , spermidine , cerebral infarction , infarction , anesthesia , stroke (engine) , cardiology , pathology , myocardial infarction , biochemistry , biology , mechanical engineering , engineering , enzyme
Polyamines are mainly restricted to the intracellular space. During focal cerebral ischemia, polyamines are released from the intracellular compartment. Experimental studies have implicated a marked elevation in brain tissue and blood. The aim of our study was to investigate whether the elevation of polyamines in the blood of patients with focal cerebral ischemia correlates with the clinical outcome and the infarct volume.

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