Ethanol-Induced Contractions in Cerebral Arteries | Zendy

Zhiwei Yang | Zendy; Jun Wang | Zendy; Tao Zheng | Zendy; Bella T. Altura | Zendy; Burton M. Altura | Zendy

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Ethanol-Induced Contractions in Cerebral Arteries

Author(s) -

Zhiwei Yang,

Jun Wang,

Tao Zheng,

Bella T. Altura,

Burton M. Altura

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.1.249

Subject(s) - medicine , cerebral arteries , endocrinology , genistein , mapk/erk pathway , vascular smooth muscle , vasoconstriction , kinase , protein kinase a , antagonist , biology , microbiology and biotechnology , receptor , smooth muscle

The relationship between alcohol consumption and stroke appears complex; moderate ingestion is associated with reduced stroke risk, while heavy intake is associated with increased stroke risk. Ethanol has been shown both experimentally and epidemiologically to induce hemorrhagic and ischemic strokes, which are associated with cerebral vasoconstriction. Ethanol is known to induce contraction in isolated cerebral arteries and intact microvessels from diverse mammalian animals. The relationships between ethanol-induced contractions in cerebral arteries, intracellular free Ca(2+) ([Ca(2+)](i)), tyrosine kinases (including the src family), and mitogen-activated protein kinases (MAPK) were investigated in the present study.

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