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Antibody to the α4 Integrin Decreases Infarct Size in Transient Focal Cerebral Ischemia in Rats
Author(s) -
Kyra J. Becker,
Darin L Kindrick,
Jane K. Relton,
John Harlan,
Robert K. Winn
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.32.1.206
Subject(s) - medicine , ischemia , antibody , stroke (engine) , middle cerebral artery , lymphocyte , inflammation , anesthesia , infarction , immunology , pathology , endocrinology , myocardial infarction , engineering , mechanical engineering
Inflammation, a process that involves neutrophils, lymphocytes, and monocytes, contributes to cerebral ischemic injury. Blockade of neutrophil adhesion to endothelium improves outcome after experimental stroke. In this study we sought to assess the contribution of lymphocytes and monocytes to ischemic brain injury.

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