Gene Transfer of Extracellular Superoxide Dismutase Increases Superoxide Dismutase Activity in Cerebrospinal Fluid | Zendy

Hiroshi Nakane | Zendy; Yi Chu | Zendy; Frank M. Faraci | Zendy; Larry W. Oberley | Zendy; Donald D. Heistad | Zendy

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Gene Transfer of Extracellular Superoxide Dismutase Increases Superoxide Dismutase Activity in Cerebrospinal Fluid

Author(s) -

Hiroshi Nakane,

Yi Chu,

Frank M. Faraci,

Larry W. Oberley,

Donald D. Heistad

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.1.184

Subject(s) - superoxide dismutase , cisterna magna , cerebrospinal fluid , dismutase , microbiology and biotechnology , extracellular , andrology , chemistry , endocrinology , medicine , biochemistry , enzyme , biology

Copper-zinc superoxide dismutase (CuZnSOD) is expressed intracellularly, while extracellular SOD (EC-SOD) is released from cells. The purpose of this study was to determine whether gene transfer of CuZnSOD increases SOD activity predominantly in tissues, and gene transfer of EC-SOD increases SOD activity in cerebrospinal fluid (CSF). We also determined whether heparin or dextran sulfate releases EC-SOD into CSF.

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