Relaxant Effect of U0126 in Hemolysate-, Oxyhemoglobin-, and Bloody Cerebrospinal Fluid–Induced Contraction in Rabbit Basilar Artery | Zendy

Alexander Y. Zubkov | Zendy; K. Shadon Rollins | Zendy; Bennett McGehee | Zendy; Andrew D. Parent | Zendy; John H. Zhang | Zendy

Open Access

Relaxant Effect of U0126 in Hemolysate-, Oxyhemoglobin-, and Bloody Cerebrospinal Fluid–Induced Contraction in Rabbit Basilar Artery

Author(s) -

Alexander Y. Zubkov,

K. Shadon Rollins,

Bennett McGehee,

Andrew D. Parent,

John H. Zhang

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.32.1.154

Subject(s) - basilar artery , medicine , cerebral vasospasm , bloody , vasospasm , contraction (grammar) , cerebrospinal fluid , mapk/erk pathway , subarachnoid hemorrhage , anesthesia , vasoconstriction , cerebral arteries , endocrinology , kinase , surgery , biochemistry , biology

It has been suggested that mitogen-activated protein kinase (MAPK) is involved in cerebral vasospasm after subarachnoid hemorrhage. The present study was undertaken to explore the inhibitory effect of U0126, a novel MAPK inhibitor, in the contraction of the rabbit basilar artery by 3 spasmogens: hemolysate, oxyhemoglobin, and bloody cerebrospinal fluid (CSF) from patients with vasospasm.

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