A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor | Zendy

Yoshinori Toshima | Zendy; Shin’ichi Satoh | Zendy; Ichiro Ikegaki | Zendy; Toshio Asano | Zendy

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A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor

Author(s) -

Yoshinori Toshima,

Shin’ichi Satoh,

Ichiro Ikegaki,

Toshio Asano

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.9.2245

Subject(s) - medicine , fasudil , neuroprotection , fibrin , thrombus , anesthesia , middle cerebral artery , rho kinase inhibitor , common carotid artery , stroke (engine) , pharmacology , ischemia , kinase , rho associated protein kinase , carotid arteries , mechanical engineering , engineering , immunology , biology , microbiology and biotechnology

The aim of this study was to develop a new model of stroke based on endothelial damage and thrombotic occlusion in a perforating artery, leading to small cerebral infarcts and neurological deficits in rats. Moreover, the neuroprotective efficacy of fasudil, a rho-kinase inhibitor, was investigated in this model.

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