Effects of Estrogen on Leukocyte Adhesion After Transient Forebrain Ischemia | Zendy

Roberto A. Santizo | Zendy; Susan Anderson | Zendy; Shuhua Ye | Zendy; Heidi M. Koenig | Zendy; Dale A. Pelligrino | Zendy

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Effects of Estrogen on Leukocyte Adhesion After Transient Forebrain Ischemia

Author(s) -

Roberto A. Santizo,

Susan Anderson,

Shuhua Ye,

Heidi M. Koenig,

Dale A. Pelligrino

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.9.2231

Subject(s) - medicine , ischemia , estrogen , intravital microscopy , neuroprotection , endocrinology , adhesion , ovariectomized rat , microcirculation , chemistry , organic chemistry

Recent findings indicate that estrogen (ie, 17beta-estradiol [E(2)]) provides neuroprotection in models of transient global and focal ischemia. Enhanced postischemic leukocyte adhesion and infiltration have been linked to neuropathology in the brain as well as other tissues. We recently showed that estrogen reduces leukocyte adhesion in the cerebral circulation of female rats during resting conditions.

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