Effects of Delayed Intraischemic and Postischemic Hypothermia on a Focal Model of Transient Cerebral Ischemia in Rats | Zendy

Nobuyuki Kawai | Zendy; Masanobu Okauchi | Zendy; Kuniaki Morisaki | Zendy; Seigo Nagao | Zendy

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Effects of Delayed Intraischemic and Postischemic Hypothermia on a Focal Model of Transient Cerebral Ischemia in Rats

Author(s) -

Nobuyuki Kawai,

Masanobu Okauchi,

Kuniaki Morisaki,

Seigo Nagao

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.8.1982

Subject(s) - medicine , hypothermia , ischemia , neuroprotection , anesthesia , infarction , cerebral infarction , brain ischemia , myocardial infarction

Intraischemic mild hypothermia has been shown to be neuroprotective in reducing cerebral infarction in transient focal ischemia. As a more clinical relevant issue, we investigated the effect of delayed intraischemic and postischemic hypothermia on cerebral infarction in a rat model of reversible focal ischemia. We also examined the effect of hypothermia on the inflammatory response after ischemia-reperfusion to assess the neuroprotective mechanism of brain hypothermia.

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