White Matter Injury in Spinal Cord Ischemia
Author(s) -
Georgios K. Kanellopoulos,
XiaoMing Xu,
Chung Y. Hsu,
Xiaobin Lü,
Thoralf M. Sundt,
Nicholas T. Kouchoukos
Publication year - 2000
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.31.8.1945
Subject(s) - nbqx , medicine , ischemia , anesthesia , white matter , ampa receptor , spinal cord , saline , kainate receptor , nmda receptor , glutamate receptor , receptor , magnetic resonance imaging , psychiatry , radiology
Spinal cord ischemia is a serious complication of surgery of the aorta. NMDA receptor activation secondary to ischemia-induced release of glutamate is a major mechanism of neuronal death in gray matter. White matter injury after ischemia results in long-tract dysfunction and disability. The AMPA/kainate receptor mechanism has recently been implicated in white matter injury.
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